Hollywood's Hottest On-Screen Duos

George Clooney and Brad Pitt
Johnny Depp and Orlando Bloom
Seth Rogen and James Franco
Owen Wilson and Vince Vaughn
Matt Damon and Leonardo DiCaprio
George Clooney and Brad Pitt Johnny Depp and Orlando Bloom Seth Rogen and James Franco Owen Wilson and Vince Vaughn Matt Damon and Leonardo DiCaprio
By Glam Media August 21, 2008
Clooney and Pitt heat up the screen in Ocean's Eleven (pictured here), Ocean's Twelve, and Ocean's Thirteen. Look for this pair to reunite on the big screen in the upcoming Burn After Reading.
The combination of Depp's loopy Capt. Sparrow and Bloom's passionate Will Turner adds extra spice to all three Pirates of the Caribbean movies. We're keeping our fingers crossed for a fourth installment!
Rogen and Franco bring both hilarity and good looks to their hit film Pineapple Express. They also had us in stitches back in the day--when they starred together on the TV show Freaks and Geeks.
What other pair would you want crashing your biggest day? Wilson and Vaughn were the perfect partners in crime for the hit comedy Wedding Crashers. Hot and funny? Sounds like the perfect wedding guest to us!
The Departed has some serious subject matter but it can't mask the gorgeous actors on screen. Damon and Dicaprio make it hard to look away--and makes us hope for another pairing of these two.
How about a round of applause for all the casting directors responsible for these super-fun (and super-hot!) on-screen duos? From the impeccable Clooney/Pitt pairing to the hilarious Wilson/Vaughn partnership, these couplings will forever standout in Hollywood history.
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