Side-By-Side Pics Of Real Housewives Stars Who Have Sparked 'Ozempic Face' Rumors

Ever since weight-loss injections had their big boom in the early 2020s, plenty of faces in the spotlight have changed. In fact, there are numerous celebs who look totally different after using weight-loss medications like Ozempic. Reality stars have also been called out for their use of it, with weight loss being common among the women of Bravo TV's "Real Housewives" franchise. While GLP-1 injections, primarily prescribed to those who have type 2 diabetes, can help one lose weight, they can also change one's face. We've already discussed Ozempic face and the risks of the diabetes drug, but it seems like examples of it are now more common than ever.

For CNN, Dr. Paul Jarrod Frank, a celebrity cosmetic dermatologist, explained just how Ozempic face happened. The expert shared that those who used the injections "felt much better losing weight," but they also "felt they looked older." The dermatologist added that "this was due to the loss of volume in their face," which is very common with the popular drug. "Usually, with people from their mid-40s and above, once you start losing 10-plus pounds, you can get this kind of deflated look," he explained. While some of the Real Housewives have opened up about their use of medications like Ozempic and Mounjaro, others haven't addressed the rumors. Nevertheless, plenty of their faces have changed, with slimmed-down and even sunken appearances. Of course, Real Housewives stars have been known for plastic surgery, so it's hard to tell what the true cause of their facial changes is.

When "RHOBH" star Erika Jayne noticeably lost weight in 2023, fans were quick to speculate that weight-loss injections might be the cause. However, Jayne denied using weight loss drugs, telling Andy Cohen on "Watch What Happens Live," "Yes, I did come down in weight, and I did it hormonally" (via E! News). When Cohen asked if she used Ozempic, she replied, "I was going through menopause ... I went to the doctor and I said 'get it off me.'"

"RHOC" star Emily Simpson's face changed between 2022 and 2025, and the reality star attributed it to weight loss. On SiriusXM's "Jeff Lewis Live," Simpson admitted she wasn't happy with her weight and that her doctor recommended a weight-loss injection. "So I did," she revealed, adding that it "worked amazing[ly]" for her. "It made me more conscientious of what I was eating and so that was a really great kick start for me." While the star lost weight, she added that she eventually stopped using Ozempic. "It made me feel lethargic and it made me just not have a lot of energy," Simpson explained.

During an appearance on "Sherri" in 2024, "RHONJ" star Margaret Josephs revealed to host Sherri Shepherd that there is no shame in using weight-loss injections. "After menopause, it's so hard to lose weight," the reality star said, adding that Ozempic "shuts off that food noise." The star added that prior to turning to injections, she tried a super healthy lifestyle. "[Before Ozempic] I couldn't do anything. It doesn't matter if I was eating right or exercising, so I don't know why there's any shame in it if it's helpful to people."

During the first half of the 2020s, "RHONJ" star Jennifer Aydin experienced weight loss, and with that, plenty assumed that the star was using weight-loss injections. "I am not on Ozempic!" the reality star said to Andy Cohen on "Watch What Happens Live" (via E! News). She added, "I'm on Mounjaro, okay. Mounjaro 2.5. I'm sorry! I love being this weight, I love it! I have so much energy if you couldn't tell." Side-by-side photos of the Bravo star's face in 2022 and 2025 showcase just how much the injections have changed her face.

In 2025, "RHONJ" star Dolores Catania opened up about a heart procedure she had undergone, revealing that because of it, she was temporarily taken off weight-loss injections. "I gained probably 15 pounds in over a month," she revealed to E! News. "Now that I'm back on, I'm healthy and I feel much better. I'm down 10," the star shared, explaining that she was on Mounjaro. Speaking about the public's often negative reactions to weight-loss injections. Catania said, "Why would you care what someone you don't even know has to say?" 

In 2023, "RHOSLC" star Heather Gay opened up about her Ozempic journey, revealing that it took her some time to actually achieve weight loss. "I've been on it for a long time, but hadn't really seen much results. And I haven't had massive results, but enough for people to notice," she told People. "You lose five pounds, people are nicer to you ... It's just the way the world works and that makes me sad for women." Side-by-side photos of the Bravo star showcase just how much slimmer her face has gotten in recent years.

While plenty of Real Housewives whose faces transformed in recent years have admitted to weight-loss drugs, some have yet to reveal if the popular injections were something they used. One of them is "RHOC" star Shannon Beador, whose face transformation in the past decade is undeniable. Sources close to the star explained that the changes in her weight were a result of her quitting drinking and increased stress, per Radar.

During an episode of Season 5 of "RHOM," Alexia Nepola was seen giving herself an injection, and it was quickly presumed that she was yet another reality star to jump on the weight-loss injection trend. However, Nepola denied it, telling Page Six it was actually a B12 shot. "It's for energy, and it has, like, other nutrients," she said. Nevertheless, a change in Nepola's face is visible, but as always, that could also be due to natural weight loss, makeup, or cosmetic procedures. Now, be sure to also check out these HGTV stars who can't seem to dodge Ozempic rumors no matter how hard they try.