Before & After Pics Of Millennial Celebs Who Have Used Ozempic And Other GLP-1s
In recent years, GLP-1 medications like Ozempic, Mounjaro, and Wegovy have taken the world by storm. Initially prescribed to type 2 diabetes patients, they have since become popularized as a weight-loss medication. And with that, we've seen plenty of stars shed pounds. In particular, numerous millennial celebs have opened up about their experiences with GLP-1 meds.
Most millennials grew up in the '90s and 2000s, when heroin-chic and visible collarbones were all the rage. And while the Ozempic craze has undoubtedly reminded many of an era when being skinny was top priority, the truth is that plenty of the stars who opened up about their GLP-1 journeys acknowledged the health benefits that came with it. For some, it worked. For others, the side effects were too dire. Kelly Clarkson, Meghan Trainor, and Co. have remained honest, showcasing that millennials know how important transparency surrounding weight loss is, especially to the young people looking up to them.
Chrissy Teigen revealed that she was on Ozempic after her miscarriage
On an episode of her podcast "Self-Conscious" in 2025, Chrissy Teigen admitted that she used a GLP-1 medication to shed weight after suffering a miscarriage in 2020. "My body was completely stuck. I really let myself indulge when I was pregnant. So, when I had lost that baby at 20 weeks, I had probably gained an extra 40 pounds that I wasn't comfortable with," Teigen shared. The model's transparency surrounding her use of medication is not surprising to her fans, as Teigen has always stressed the importance of honesty.
Serena Williams' use of GLP-1 medication surprised many
Many were surprised to see tennis star Serena Williams partner up with the company Ro to promote GLP-1 medication, especially considering that the athlete had always lived a healthy and active life. Williams admitted that while she was always in great shape, she still struggled with stubborn weight. "Sometimes, no matter what you do, no matter how many steps you take, how many miles you run, you just can't get over that hump. I know that for a fact," the athlete said (via NBC News). "As a woman, as I age, I definitely couldn't get over that hump."
Amy Schumer revealed that she had tried Ozempic, but wasn't happy with it
In 2025, Hollywood star Amy Schumer shared on "The Howard Stern Show" that she had tried GLP-1 medication. "I tried Ozempic almost three years ago, and I was, like, bedridden. I was vomiting," she explained, adding that the side effects of the popular weight-loss injections were too much for her. It is unclear how long Schumer was on the medication, but the actor implied that she was no longer using Ozempic. Nevertheless, the star slimmed down, as before-and-after pics of Amy Schumer show just how weight loss transformed her face.
Meghan Trainor admitted to being on Mounjaro — and was loving it
On Instagram, musician Meghan Trainor acknowledged the changes in her appearance in 2025, writing, "I've worked with a dietician, made huge lifestyle changes, started exercising with a trainer, and yes, I used science and support (shoutout to Mounjaro!) to help me after my 2nd pregnancy. And I'm so glad I did because I feel great." Mounjaro is a GLP-1 medication similar to Ozempic, and as before-and-after photos show, it certainly played a significant role in Meghan Trainor's complete weight-loss transformation.
Kelly Clarkson used a weight-loss medication, but never revealed the brand name
Musician Kelly Clarkson is definitely one of the celebs who looks totally different after using weight-loss medications like Ozempic. During a 2024 episode of "The Kelly Clarkson Show", the singer revealed that she had been on a weight-loss medication. "Mine is a different one than people assume, but I ended up having to do that, too, because my bloodwork got so bad. Everybody thinks it's Ozempic. It's not," Clarkson explained. "My doctor chased me for, like, two years, and I was like, 'No, I'm afraid of it. I already have thyroid problems,'" Clarkson added.
Rebel Wilson microdosed GLP-1 medication to keep her weight steady
We've already discussed Rebel Wilson's complete weight-loss transformation in 2024, as the star had noticeably changed in recent years. In 2024, Wilson revealed that she was no stranger to microdosing GLP-1 medication as a means to help her keep the weight off. "Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good," the star shared with The Times. The star also explained that her OB-GYN suggested she explore the weight-loss medication after she had already lost a significant amount of weight due to lifestyle changes.
Lizzo tried Ozempic, but lost weight thanks to dietary changes
Musician Lizzo opened up about her weight-loss journey in 2025. "I've tried everything," the musician revealed on the "Just Trish" podcast. "It's just the science, for me, calories in vs. calories out. Ozempic works because you eat less food. It makes you feel full. So, if you can just do that on your own and get mind-over-matter, it's the same." Lizzo explained that switching from a vegan diet to a more carnivore-leaning diet helped her shed some weight, as she found herself eating plenty of carbs while vegan.
Amanda Bynes gushed about using Ozempic on social media
Former Nickelodeon star Amanda Bynes revealed that she had managed to lose weight thanks to Ozempic, sharing with her followers on Instagram that she no longer minded being photographed. "I usually don't like paparazzi pictures bc I was 180lbs but now I've lost 28lbs on Ozempic! I'm down to 152lbs. I know I still look big but this photo is really inspiring to me," the actor explained on Instagram Stories (via People). Prior to starting Ozempic, Bynes shared her excitement about the journey, explaining to her followers that she would document it online.
GLP-1 meds worked for Brooks Nader, but she had mixed feelings about them
Model Brooks Nader opened up about her usage of GLP-1 medications to Bustle in 2025, revealing that her career skyrocketed once she lost weight. "When I started GLP-1, my career took off," she said. "I lost 30 pounds, and I booked all the jobs." The star added that she felt the weight-loss medication had become a "crutch," and expressed a desire to quit. "It's not healthy. I should get off it; I'll be honest about that," she shared.
Whitney Leavitt opened up about her GLP-1 experience on social media
"Secret Lives of Mormon Wives" star Whitney Leavitt tried a little bit of everything on her weight-loss journey, including GLP-1 injections. In a 2023 YouTube video, the reality star revealed that she had been using weight loss medication. "I have been losing weight, and I have a secret sauce," she explained. "I don't know if you've heard of semaglutide. Technically, for people with type 2 diabetes, but it's regulating my blood sugar and just like, killing the fat."